Zinc Pca
Zinc PCA (CAS 68107-75-5 / 15454-75-8) is a synergistic compound combining zinc and L-pyrrolidone carboxylic acid (L-PCA). Zinc contributes to normalizing sebum production and limiting the proliferation of acne-causing bacteria, while L-PCA is a natural moisturizing factor (NMF) that supports skin hydration and enhances the bioavailability of zinc. It is officially classified under CosIng functions as a humectant and skin conditioning agent, with a cosmetic restriction listed as III/24.
Zinc PCA has demonstrated statistically significant reduction in sebum production after 28 days of use at 1% concentration in an in-vivo test. In-vitro data show strong anti-microbial activity against P. acnes at 0.1–0.25%, and a 2011 research paper suggests it may support type I collagen synthesis, pointing to potential anti-aging properties.
The source notes a cosmetic restriction (III/24), which users and formulators should be aware of. No additional specific contraindications are mentioned in the source.
