SH-Polypeptide-1
SH-Polypeptide-1, also known as Basic Fibroblast Growth Factor (FGF2) or rh-Polypeptide-1, is a single-chain synthetic human peptide produced by fermentation in E. coli. The starting gene is a synthesized copy of the human gene coding for basic fibroblast growth factor. It contains a maximum of 288 amino acids, which may include disulfide bonds and/or glycosylation, and consists of the proper sequence of the 20 standard amino acids.
SH-Polypeptide-1 is a cell-signaling protein that stimulates fibroblast cell growth and proliferation (mitogenic activity). According to manufacturer information, it also stimulates the synthesis of collagen and other extracellular-matrix components.
Growth factors in skincare are described by the source as a "big, complicated and controversial topic"; the efficacy and safety of topically applied growth factors remain debated.
