Sh-Oligopeptide-2
SH-Oligopeptide-2, also known as Insulin-like Growth Factor 1 (IGF-1), is a single-chain recombinant human peptide consisting of 70 amino acids, produced by fermentation in E. coli from a synthesized copy of the human IGF-1 gene. It belongs to the Growth Factors ingredient group, alongside its better-known counterpart SH-Oligopeptide-1 (Epidermal Growth Factor). Its official CosIng functions are listed as skin conditioning and skin protecting. The topic of growth factors in skincare is described by the source as complex and controversial.
IGF-1 is claimed to stimulate cell proliferation and wound healing. One study cited by the source indicates that IGF-1 and EGF work in synergy to promote keratinocyte (skin cell) proliferation, potentially via IGF-1 transmodulation of the EGF receptor.
The use of growth factors in skincare is described by the source as complex and controversial; readers are directed to weigh the pros and cons carefully. No specific contraindications are listed in the source.
