Potassium Azeloyl Diglycinate
Potassium Azeloyl Diglycinate (CAS 477773-67-4) is a water-soluble derivative of azelaic acid combined with the amino acid glycine. Unlike azelaic acid itself, which is insoluble in both water and oil, this derivative is easily incorporated into a wide range of cosmetic formulations. It is classified under skin conditioning by CosIng and is used as a multi-functional active targeting pigmentation, acne, and redness.
It inhibits tyrosinase, the enzyme responsible for melanin production, providing skin-brightening effects. It also demonstrates sebum-normalizing activity relevant to acne-prone skin, and carries the anti-inflammatory properties associated with its parent compound, azelaic acid. Clinical studies have shown improvement in rosacea and melasma when used in combination with other actives.
Available clinical studies combined Potassium Azeloyl Diglycinate with other actives, making it difficult to isolate its individual contribution; efficacy claims are largely based on manufacturer data and limited combination-therapy research.
