Palmitoyl Pentapeptide-4
Palmitoyl Pentapeptide-4 (also known as Matrixyl or Pal-KTTKS) is a synthetic pentapeptide composed of five amino acids in the sequence lysine–threonine–threonine–lysine–serine (KTTKS), which is a subfragment of type I collagen. It was developed jointly by ingredient supplier Sederma and Procter & Gamble. The KTTKS sequence is attached to palmitic acid (a 16-carbon fatty acid) to improve oil solubility and skin penetration. It functions as a cell-communicating ingredient and is officially classified under skin conditioning by CosIng.
Clinical studies indicate that Palmitoyl Pentapeptide-4 can reduce fine lines and wrinkles and improve skin texture significantly, even at very low concentrations (as low as 3 ppm / 0.0003%). One study found it showed comparable wrinkle-improving ability to 0.07% retinol, with better skin tolerability.
Most available research is manufacturer-sponsored, which should be considered when evaluating the strength of evidence.
