Hydrolyzed Hyaluronic Acid
Hydrolyzed Hyaluronic Acid is a low molecular weight, chemically fragmented version of Hyaluronic Acid (HA), produced via acid, enzyme, or other hydrolysis methods. It is available in multiple molecular weight ranges (e.g., 100–300 kDa, 50 kDa, ~10 kDa), each with distinct skin penetration depths and functional properties. As a smaller molecule compared to standard HA, it is claimed to penetrate the skin more readily than its high-molecular-weight counterpart.
Acts as a humectant to help the skin retain water, contributing to plumpness and elasticity. The 100–300 kDa fraction may support skin self-defense and wound healing, and is noted as particularly suitable for sensitive, acne-prone, or rosacea-affected skin. The ~50 kDa fraction is associated with absorption into the skin and reduction of the appearance of wrinkles.
Ultra-low molecular weight versions (below ~50 kDa) are considered controversial, as research by Evonik suggests that very low molecular weight HA naturally acts as a pro-inflammatory signal molecule in the body; individuals with inflammatory skin conditions should be aware of this distinction.
