Acetyl Hexapeptide-8 (5.1 Ppm)
Acetyl Hexapeptide-8 (also known as Argireline or Acetyl Hexapeptide-3) is a synthetic peptide composed of arginine, methionine, and acetylated glutamic acid residues with CAS # 616204-22-9. It is marketed as a "Botox-like" ingredient because it targets wrinkles caused by facial muscle movement, though its mechanism and efficacy differ significantly from Botox. It is classified by CosIng as a humectant and skin-conditioning agent.
In-vivo studies showed a 10% Argireline solution applied around the eyes for 15 days reduced wrinkle depth by 17%, and a 5% formula applied for 28 days reduced wrinkle depth by approximately 16.26%. Research from a Spanish University found it increased skin moisturization and significantly decreased both the depth and width of wrinkles. It is considered a quick-fix for wrinkle smoothing rather than a structural anti-aging treatment like vitamin C, AHAs, or retinol.
The source notes it is not a collagen builder and does not address structural aging; its wrinkle-relaxing effect is considerably less pronounced than Botox despite similar marketing claims.
