Acetyl Hexapeptide-8
Acetyl Hexapeptide-8 (also known as Argireline or Acetyl Hexapeptide-3) is a synthetic peptide composed of arginine, methionine, and acetylated glutamic acid residues (CAS #616204-22-9). It is marketed as targeting the same wrinkle-forming mechanism as Botox — specifically wrinkles caused by facial muscle movement — though its mechanism and extent of effect are notably different. It is classified by CosIng as a humectant and skin-conditioning ingredient.
In-vivo studies showed a 10% Argireline solution applied around the eyes for 15 days decreased wrinkle depth by 17%, and a 5% formula applied for 28 days decreased wrinkle depth by 16.26%. Independent university research found it increased skin moisturization and significantly decreased both the depth and width of wrinkles. It is considered a quick-fix for wrinkle smoothing rather than a structural anti-aging treatment like vitamin C, AHAs, or retinol.
The source notes it is not a collagen builder and does not address structural aging; its wrinkle-relaxing effect is considerably less pronounced than Botox injections.
